Alyce Frank was born in New Iberia, Louisiana in 1932. She then moved to Los Angeles, California and Tulsa, Oklahoma at a young age. At the age of 15, she applied to a liberal arts program and was accepted at the University of Chicago, graduating three years later. After graduating from the University of Chicago in 1950, she moved to Los Angeles, where she attended graduate school at UCLA and the University of Southern California (USC). At USC she met Larry Frank, as aspiring filmmaker; they married in 1953.
For ten years, she worked on educational films that her husband produced. Her work as a film editor helped cultivate her sense of composition, something that served her well when she took up painting.
She moved to New Mexico when she in 1962 and began painting in 1973, specializing in boldly colored landscape paintings influenced by fauvism and German expressionism.
In 1983, she was selected for a masterclass with Richard Diebenkorn at the Santa Fe Institute of Art.
Frank collaborates with many artists in nearby Taos, New Mexico and refers to herself as a “Taos Expressionist”. She is a long time painting partner of Taos artist Barbara Zaring.
Over 26 years, she created a large body of work, completing more than 600 canvases, primarily large landscapes as well as nearly one hundred portraits.
Her works were collected into the book The Magical Realism of Alyce Frank by Joseph Dispenza in 1999.
Her painting The Upper Falls at Yosemite (ca. 1996) was part of an exhibition on the art of Yosemite which appeared at the Autry National Center, the Oakland Museum of California, the Nevada Museum of Art and the Eiteljorg Museum of American Indians and Western Art from 2006 to 2008.
She is a resident of Arroyo Hondo, New Mexico and was married to Larry Frank, a filmmaker and author, until his death. They collected Native American and Hispano American art and artifacts and they had three children.